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Substituted piperidines as modulators of dopamine neurotransmission

The present invention relates to compounds having therapeutic effects against disorders in the central nervous system, and in particular substituted hydroxypiperidines of the formula 1: ##STR00001## wherein R1, R2, and R3 are as defined herein. Compounds with modulating effects on dopaminergic systems may also be used to improve cognitive functions and in the treatment of emotional disturbances related to ageing, neurodegenerative (e.g. Dementia and age-related cognitive impairment) and developmental (such as Autism spectrum disorders, ADHD, Cerebral Palsy, Gilles de la Tourette’s syndrome) disorders as well as after brain injury.

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