Cerebral Palsy Patents - Part 2

System and Method Suitable for Treatment of a Patient with a Neurological Deficit by Sequentially Stimulating Neural Pathways Using a System of Discrete Implantable Medical Devices
  • Type(s): Medical Equipment
  • Inventor(s): Cosendai; Gregoire (Cudrefin, CH), Zilberman; Ytizhak (Santa Clarita, CA), Kuschner; Doug (Santa Clarita, CA), Ripley; Anne Marie (Los Angeles, CA), Turk; Ruth (Farnham, GB), Burridge; Jane (Salisbury, GB), Notley; Scott V. (Southhampton, GB), Davis; Ross (Melbourne Beach, FL), Hansen; Morten (Valencia, CA), Mandell; Lee Jay (West Hills, CA), Schulman; Joseph H. (Santa Clarita, CA), Dell; Robert Dan (Valancia, CA), Gord; John C. (Venice, CA)
  • Patent Number: 11/004,758
  • USPTO Link

A system and method that facilitates stimulating neural pathways, e.g., muscles and/or associated nerves, of a patient’s body for the purpose of therapeutic medical treatment by rehabilitating weakened muscles and using neuroplasticity to retrain sequential muscle movements and/or to provide the ability to directly deliver functional motor movements. Use of the present invention is of particular value for treating a patient following a stroke. More particularly, such systems are characterized by a plurality of discrete devices, preferably battery powered but may alternatively include RF-powered devices as well or in combination, configured for implanting within a patient’s body via injection, each device being configured to affect a parameter, e.g., via nerve and/or muscle stimulation and/or to sense a body parameter, e.g., temperature, O.sub.2 content, physical position, electrical potential, etc., that operate under control of a system controller that coordinates the sequential stimulation via wireless commands to the implanted devices.  The described functions and devices could be equally useful in treating other neurological deficits, e.g., foot drop following a stroke, multiple sclerosis, cerebral palsy, spinal cord injury, etc.,

Nerve Stimulation for Treating Spasticity, Tremor, Muscle Weakness, and Other Motor Disorders
  • Type(s): Medicine
  • Inventor(s): Ayal; Shai (Jerusalem, IL), Cohen; Ehud (Ganei Tikva, IL), Dabby; Ron (Raanana, IL)
  • Patent Number: 10/981,939
  • USPTO Link

A method for treating spasticity of a subject is provided, including driving a current into a nerve of the subject that includes one or more sensory fibers, and configuring the current so as to inhibit propagation of action potentials in one or more of the sensory fibers, so as to treat the spasticity. In a preferred embodiment, the sensory fibers include one or more Ia sensory fibers, and configuring the current includes configuring the current so as to inhibit propagation of the action potentials in at least one of the Ia sensory fibers.  There are a number of known causes of spasticity, tremors, and muscle weakness, including cerebral palsy, traumatic brain and spinal cord injury.

Tetrahydroindolone Derivatives for Treatment of Neurological Conditions
  • Type(s): Medicine
  • Inventor(s): Helton; David R. (Foothill Ranch, CA), Fick; David B. (Newport Beach, CA), Sharp; Jason P. (San Clemente, CA), Pfadenhauer; Ernest H. (Costa Mesa, CA)
  • Patent Number: 10/595,219
  • USPTO Link

Compositions comprising tetrahydroindolone derivatives in which the tetrahydroindolone moiety is covalently linked to a substituted arylpiperazine moiety and methods for treating neurological and psychiatric conditions using such compositions are disclosed. Cognitive and other neurological disorders that can be effectively treated using the present compounds and pharmaceutical compositions include conditions such as, but not limited to, neurosensory diseases and injury, Parkinson’s disease and other movement disorders such as dystonia, Wilson’s disease, inherited ataxias, Tourettes syndrome cerebral palsy, encephalopathies.

Treating Neurological Disorders Using Selective Antagonists of Persistent Sodium Current
  • Type(s): Medicine
  • Inventor(s): Ehring; George R. (Huntington Beach, CA), Adorante; Joseph S. (Irvine, CA), Wheeler; Larry A. (Irvine, CA), Malone; Thomas (Irvine, CA), Whitcup; Scott M. (Laguna Hills, CA)
  • Patent Number: 10/928,949
  • USPTO Link

The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current. Exemplary examples of neuropathies include, without limitation, amyloidosis; ; movement disorders like palsies involving injury or damage to nerves such as, e.g., cerebral palsy.

Methods of Synthesizing N-hydroxysuccinimidyl Carbonates
  • Type(s): Medicine
  • Inventor(s): Boddupalli; Sekhar (San Jose, CA), Walkinshaw; Gail (San Jose, CA), Wang; Bing (Cupertino, CA)
  • Patent Number: 10/630,170
  • USPTO Link

The present invention is concerned with novel furanone derivatives that are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. Such furanone derivatives are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress, and particularly, in providing neuroprotection in the event of cerebral ischemia, even when administered a significant time interval after an ischemic insult. In particular, the compositions of the present invention are useful in the treatment of stroke, as demonstrated by providing neuroprotection in a standard experimental model of focal cerebral ischemia. They are also useful in the treatment of neuroinflammation, cognitive disorders and neurodegenerative diseases such as neuropathy in cerebrovascular diseases, brain trauma, cerebral palsy, epilepsy, amyotrophic lateral sclerosis (ALS), Huntington’s disease, mental diseases (e.g. psychosis, schizophrenia, depression), Parkinson’s disease, Friedreich’s disease, Down’s syndrome, Creutzfeldt-Jakob syndrome, Alzheimer’s disease, and senile dementia.

Method for Regulating Neuron Development and Maintenance
  • Type(s): Medicine
  • Inventor(s): Bartlett; Perry (North Carlton, AU), Murphy; Mark (Fitzroy, AU)
  • Patent Number: 10/422,552
  • USPTO Link

The method according to claim 27 or 28 wherein the disease or injury is Cerebral Palsy, trauma induced paralysis, vascular ischaemia associated with stroke, neuronal tumours, motorneuron disease, Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, Huntington’s disease, peripheral neuropathies associated with diabetes, heavy metal or alcohol toxicity, renal failure and/or infectious disease

Electromagnetic Therapy Device and Methods
  • Type(s): Medical Equipment
  • Inventor(s): Whelan; Andrew J. (Frederick, MD), Martinez; John (Houston, TX), Cox; Timothy (Friendswood, TX), Toy; Stephanie (League City, TX), Woodhams; James (Escondido, CA)
  • Patent Number: 10/384,101
  • USPTO Link

Systems and techniques for applying an electromagnetic field to bodily tissue include a self-contained and portable electromagnetic field generating device disposed over a surface of bodily tissue such that the radiated electromagnetic fields impinge upon the bodily tissue. The device includes an electromagnetic field generator, which is coupled to an antenna that is arranged to radiate the electromagnetic field. A power source is coupled to the generator to provide power for the device and an activator is used to initiate radiation of the electromagnetic field. cerebral palsy, mental retardation, hyperactivity, learning disabilities may be improved by PEMF stimulation of the central nervous system.

Methods for Treating a Neurological Disorder by Peripheral Administration of a Transforming Growth Factor Alpha (TGF-a)
  • Type(s): Medicine
  • Inventor(s): Fallon; James H. (Irvine, CA), Kinyamu; Richard M. (Irvine, CA)
  • Patent Number: 10/167,384
  • USPTO Link

The invention provides methods of treating a subject having a disease, disorder or condition of the central nervous system. The methods include administering TGF-.alpha. polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating progenitor cell or stem cell proliferation, migration and differentiation. The methods of the invention are useful to treat and prophylactically ameliorate neurological tissue injury in vivo.

Method of Neurosurgical Treatment of Infantile Cerebral Palsy
  • Type(s): Medicine
  • Inventor(s): Svadovskiy; Aleksandr Igorevich (Moscow 105187, RU)
  • Patent Number: 10/134,331
  • USPTO Link

A method of neurosurgical treatment of infantile cerebral palsy wherein laminectomy is performed for providing access to the vertebral canal and its contents. The laminectomy is carried out in the cervical portion of the spine and the removal of at least three vertebral arches is effected.

Method and Device for Rehabilitation of Motor Dysfunction
  • Type(s): Medical Equipment
  • Inventor(s): Cordo; Paul J. (Portland, OR)
  • Patent Number: 10/062,742
  • USPTO Link

A method and device for the rehabilitation of patients that have suffered loss of motor control of an appendicular joint due to neurological damage. The method includes attempted contraction by a patient of a muscle that serves to move an affected joint coupled with the production of a perception by the patient that the joint is being moved more than it really is. The method results in dramatic non-transient improvements in motor control of the joint. The device provides an apparatus for performance of the method. . The method of claim 18, in which the neurological disorder is one of stroke, spinal cord injury, multiple sclerosis, dystonia, cerebral palsy, or head injury.

Methods for Treating Neurological Injuries and Disorders
  • Type(s): Medical Equipment
  • Inventor(s): Marchionni; Mark (Arlington, MA), Jarpe; Michael (Marlborough, MA), Ebendal; Ted (Uppsala, SE)
  • Patent Number: 09/756,481
  • USPTO Link

The present invention relates to methods for treatment of nerve cell death (degeneration) and neurodegenerative diseases. Methods of the invention include administering, an effective amount of GDF-1 alone or in combination with neurotrophin-3, to a patient in need of such treatment such as a person suffering from stroke or traumatic brain injury or a neurodegenerative disease. . Therapies of the invention are particularly effective for the treatment or prophylaxis of the effects of stroke, brain or spinal cord injury or ischemia, heart attack, optic nerve and retinal injury and ischemia and other acute-type conditions disclosed herein as well as chronic-type neurodegenerative conditions, such as epilepsy, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic Lateral Sclerosis, Down’s Syndrome, Korsakoff’s disease, cerebral palsy and/or age-dependent dementia.

Neurosurgical Guide Device
  • Type(s): Medical Equipment
  • Inventor(s): Gill; Steven (Old Bury on Severn, GB)
  • Patent Number: 09/728,696
  • USPTO Link

The present invention relates to a neurosurgical guide device for use in neurosurgery. The device is particularly useful in stereotactically targeted surgical treatment of abnormalities of brain function. The neurosurgical guide device comprising a tube for insertion into a brain of a patient to a vicinity of a desired target, wherein the tube has a head attached to one end thereof, and whereby an instrument can be introduced through the opening and passed along the bore from a proximal end to a distal end thereof. The device is particularly useful in stereotactically targeted surgical treatment of abnormalities of brain function, including abnormalities of movement such as Parkinson’s disease, chorea, tremor, multiple sclerosis and cerebral palsy.

Methods for Improving Central Nervous System Functioning
  • Type(s): Medicine
  • Inventor(s): Kraus; Morey (Jefferson, MA), Finklestein; Seth (Needham, MA), Clark; Paul (Wellesley, MA)
  • Patent Number: 09/698,893
  • USPTO Link

Methods of causing an improvement in central nervous system function are provided. The methods include administering an aliquot of stem cells to the patient, the cells being derived from blood, e.g., umbilical cord blood. In some cases a growth factor is administered with the cells. The improvement results from treatment of one of the following diseases: Parkinson’s Disease, Alzheimer’s Disease, Huntington’s Disease, ALS, MS, Tay-Sacks, and cerebral palsy.

Pharmaceutical Composition for Neurotrophic Action
  • Type(s): Medicine
  • Inventor(s): Miyamoto; Masaomi (Takarazuka, JP), Kato; Koki (Kobe, JP), Ishihara; Yuji (Ibaraki, JP)
  • Patent Number: 09/673,057
  • USPTO Link

The present invention provides a composition for neurotrophic action which comprises a compound of the formula: ##STR1## wherein Ar is an optionally condensed phenyl group which may be substituted; n is an integer of 1 to 10; R is a hydrogen atom or a hydrocarbon group which may be substituted; and Y is an amino group which may be substituted or a nitrogen-containing saturated heterocyclic group which may be substituted; or a salt thereof, which compounds are useful for preventing and/or treating (1) neurodegenerative diseases (e.g. senile dementia, Alzheimer’s disease, Down’s syndrome, Parkinson’s disease, Creutzfelt-Jakob disease, amyotrophic lateral sclerosis, diabetic neuropathy, etc.), (2) neuropathy in cerebrovascular diseases (e.g. impairment of cerebral blood flow based on cerebral infarction, cerebral hemorrhage, cerebral sclerosis, etc.), brain trauma, spinal cord injury, cerebritis sequela and cerebral palsy, (4) mental diseases (e.g. depression, panic disorder, schizophrenia, etc.), etc.

Photomatrix Device
  • Type(s): Medical Equipment
  • Inventor(s): Zharov; Vladimir Pavlovich (Moscow, RU)
  • Patent Number: 09/646,824
  • USPTO Link

A device for the physiotherapeutic irradiation of spatially extensive pathologies by light with the help of a matrix of the sources of optical radiation such as lasers or light diodes placed on the surface of a substrate whose shape is adequate to the shape of the zone of pathology is disclosed. In addition, the device contains stops and a holder to fix the substrate against the bioobject. Additional modules are provided to adjust the temperature, pressure, gas composition over the pathological area. The substrate 13 in form of a semi-sphere is employed to irradiate the head in both cosmetology to treat baldness and activate the brain bloodflow at rehabilitation of patients affected by insult or cerebral palsy.

Treatment of Brain Damage
  • Type(s): Medical Equipment
  • Inventor(s): Hodges; Helen (London, GB)
  • Patent Number: 09/537,617
  • USPTO Link

The following diseases and pathological conditions are examples of diseases or conditions which result in deficits which may be treated in accordance with the present invention: traumatic brain injury, stroke, perinatal ischaemia, including cerebral palsy, Alzheimer’s, etc.

Therapy Device for Upper Extremity Dysfunction
  • Type(s): Medical Equipment
  • Inventor(s): Dunlevy; Mindy (Winter Springs, FL), Dunlevy; Michael (Winter Springs, FL)
  • Patent Number: 09/405,673
  • USPTO Link

An increasing percentage of the United States population suffers from motor planning dysfunction’s and abnormal muscle tones as a result of various etiologies such as but not limited to Cerebral Vascular Accidents(CVA), head injuries and cerebral palsy.

Methods of Inducing Nervous Tissue Regeneration
  • Type(s): Medical Equipment
  • Inventor(s): Weinstein; David E. (Dobbs Ferry, NY)
  • Patent Number: 09/294,764
  • USPTO Link

This invention relates to a method of regenerating nervous tissue by contacting the tissue with Schwann cells that express .DELTA.SCIP. The inventors have demonstrated herein that Schwann cells expressing .DELTA.SCIP induce regeneration of nervous tissue. Also provided by the present invention is a method for treating a subject in need of nervous tissue regeneration by introducing Schwann cells expressing .DELTA.SCIP into the subject. Non-limiting examples of neurodegenerative diseases which may be treated using the methods described herein are Alzheimer’s disease, cerebral palsy  etc.

Corona Discharge Beam Treatment of Neuro-Cerebral Disorders
  • Type(s): Medicine
  • Inventor(s): Di Mino; Alfonso (Woodcliff, NJ), Di Mino; Andre (Woodcliff, NJ)
  • Patent Number: 09/224,441
  • USPTO Link

The frontal lobes of the brain constitute about 30 percent of the cerebrum. Of the various effects of frontal lobe lesions, most is known about motor abnormalities caused thereby, such as spastic paralysis. Those abnormalities in motor functions which are referred to as cerebral palsy are characterized pathologically by cerebral lesionsA non-invasive therapeutic technique for treating neuro-cerebral disorders such as multiple sclerosis that are characterized by internal lesions in brain tissue. In this technique, directed toward an external site on the body of the subject to be treated adjacent the internal lesions is a pulsatory corona discharge beam which impinges on the site and bombards the lesions with ions to alleviate the disorder.

Pyridazinedione Compounds Useful in the Treating Neurological Disorders
  • Type(s): Medicine
  • Inventor(s): Bare; Thomas Michael (West Chester, PA), Sparks; Richard Bruce (Linwood, PA)
  • Patent Number: 08/689,259
  • USPTO Link

More specifically, the compounds are useful in the treatment of strokes and/or other neurodegenerative disorders such as hypoglycemia, cerebral palsy,etc.

Splint/Therapeutic Device
  • Type(s): Medical Equipment
  • Inventor(s): Gray; James C. (Knoxville, TN)
  • Patent Number: 08/559,159
  • USPTO Link

An improved splint/therapeutic device for at least partially immobilizing a portion of a patient’s body. The device includes a splint body fabricated of a resilient material, the splint body defining an inner surface for engaging the patient’s body. The splint body also defines a preselected flexibility whereby the resilient material of the splint body biases the patient’s body to a desired body position and provides a preselected degree of mobility. . Such devices are desirable especially with cerebral palsy patients, patients who have suffered strokes, persons who have had tendon surgery and persons who suffer from or are susceptible to carpal tunnel syndrome.