Cerebral Palsy Patents

The United States Patent and Trademark Office grants property rights to inventors in order to protect their intellectual property. Today, the U.S. Patent Office, maintains a comprehensive website that allows people to search for patents related to specific industries.

Under the terms of patent protection in the United States, the owner of a patent has the rights to manufacture or license a product that they develop for a period of 20 years from the date of the application filing.

We have selected several past and current patents that may prove useful to people with cerebral palsy. There are many more patents related to cerebral palsy that can be viewed via the patent office website. If interested in the particular patent or product, you may wish to contact the inventor directly.

Patella Alignment Device
  • Type(s): Medical Equipment
  • Inventor(s): Hoffman; Maxine (Dayton, OH), Doepker; Philip (Dayton, OH), Mitchell; Austin (Pittsburgh, PA), Northridge; Jessica Marie (Xenia, OH), Petit; Daniel James (Wooster, OH)
  • Patent Number: 12/944,613
  • USPTO Link

One embodiment of the invention is a knee (or elbow) band assembly 100 that has a pocket assembly 106 containing a flexible pad 200 with rounded surfaces 112b, 116b separated by a valley 114b. The band assembly 100 is applied to a leg below the knee or to an arm above the elbow to improve body alignment and function and to relieve pain. The rounded surfaces 112a, 116a apply pressure to the limb to aid in alignment of the patellar or triceps tendons and to activate pressure points on the skin to stimulate the release of tension in the body and to stimulate the body’s natural self-curative abilities.      Placement of the band assembly 100 on the arm(s) and leg(s) of children with cerebral palsy decreases flexion (bent) holding patterns and allows for better arm and leg extension for improved walking and arm and hand use. It can decrease ataxic (uncoordinated) movements by stabilizing the knee and elbow joints.

Therapeutic Exercise Apparatuses
  • Type(s): Medical Equipment
  • Inventor(s): Dauterive; Ross (Las Vegas, NV)
  • Patent Number: 12/705,263
  • USPTO Link

Handicapped children, particularly those with cerebral palsy typically suffer trismatic spasms which may eventually dislocate the femur from the hip sockets. Remedies for this problem include major surgery every two to three years. Thus, the need exists for systems and methods that enable a handicapped person to exercise their hips and legs to help prevent hip dislocation and muscle atrophy.

Device and Method for Improving Human Motor Function
  • Type(s): Medical Equipment
  • Inventor(s): Bar-Haim; Simona (Beer Yaakov, IL), Belokopytov; Mark (Karnei Shomron, IL)
  • Patent Number: 11/861,316
  • USPTO Link

It is provided a system for improving locomotion of a human user, by changing an inclination or height of a stance surface of a device for donning on a leg during walking. The system includes a device, a sensor and a microprocessor. The device includes a platform which securely receives the shoe or foot of the user, a sole and mechanisms between the platform and the sole. Each mechanism has a motor and a thrusting element which changes the height of the platform relative to the sole. The sensor is associated with the lower limb, it senses the locomotion of the user and issues a corresponding data signal to the microprocessor. The microprocessor processes the locomotion information, determines the locomotion phase, and controls the mechanisms to effect changing of the inclination and/or the height of the stance surface during a swing phase. Also, the microprocessor introduces random changes thereof.

Pathology Related Individual Modular Orthopedic Seating System
  • Type(s): Medical Equipment
  • Inventor(s): van den Nieuwboer; Johanna Hendrika (Haaksbergen, NL), de Vries; Jacob (Boekelo, NL)
  • Patent Number: 11/881,127
  • USPTO Link

A wheelchair sit-system with a three dimensional anatomical shape, which can accomplish an equal as well as an unequal pressure/load distribution, stabilize the pelvic base and trunk, compensate sit pathology, and be individually adapted on the basis of treatment of specific sit complaints/impairments. The wheelchair sit system (i.e., a sit cushion and a backrest) is developed methodically via inventory of the three dimensional pelvis/trunk measures; design a three dimensional drawing of basic sit cushions and backrest models in three sizes (S, M and L); specification of the sit pathology of the pelvis and trunk; and modification of the designed three dimensional basic sit cushion and backrest models on the basis of sit pathology. A product development trajectory results in nine sit cushion models in three sizes (S, M and L); six backrest models in three sizes (S, M and L); one generic sit cushion, with inserts, in three sizes (S, M and L); and one generic backrest, with inserts, in three sizes (S, M and L). The assortment of sit cushions and backrest models is applied via a prescription procedure has been developed.

MG53 Compositions and Methods of use
  • Type(s): Medicine
  • Inventor(s): Ma; Jianjie (Belle Mead, NJ), Weisleder; Noah (Elizabeth, NJ), Cai; Chuanxi (Highland Park, NJ)
  • Patent Number: 12/307,303
  • USPTO Link

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins. Also within the scope of the invention is the use of a therapeutic of the invention in the manufacture of a medicament for treating or preventing disorders or syndromes including, e.g., cardiovascular disease, cardiomyopathy, atherosclerosis, hypertension, congenital heart defects, Parkinson’s disease, Huntington’s disease, cerebral palsy.

Botulinum Toxin Neurotoxic Component for Treating Juvenile Cerebral Palsy
  • Type(s): Medicine
  • Inventor(s): Graham; Herbert Kerr (Melbourne, AU)
  • Patent Number: 11/752,096
  • USPTO Link

The invention provides for the use of a presynaptic neurotoxin (for example a bacterial neurotoxin such as botulinum toxin A) for the manufacture of a medicament for the treatment of cerebral palsy in juvenile patients. The juvenile patients are preferably juveniles of up to 6 years in age.

Herbal Composition for Treatment of Neurodegeneration and Neuronal Dysfunction
  • Type(s): Medicine
  • Inventor(s): Xia; YongChao (GanSu Province, CN)
  • Patent Number: 11/735,101
  • USPTO Link

This formulation consists of 14 ingredients and was invented by Dr. YongChao Xia (Provincial Hospital of Chinese medicine. LanZhou, P.R. China). BuNaoGao was designed to treat various forms of neuronal injuries and neuronal dysfunctions and neurodegeneration, i.e. head, and spinal cord injury, cerebral palsy, motor neuron diseases (1-5).

Meridamycin Analogues for the Treatment of Neurodegenerative Disorders
  • Type(s): Medicine
  • Inventor(s): Graziani; Edmund Idris (Chestnut Ridge, NY), Pong; Kevin (Robbinsville, NJ)
  • Patent Number: 11/713,972
  • USPTO Link

Conditions affecting the central nervous system include, but are not limited to, epilepsy, stroke, cerebral ischemia, cerebral palsy, multiple sclerosis, etc.

Electrical Stimulation Device and Method for the Treatment of Neurological Disorders
  • Type(s): Medical Equipment
  • Inventor(s): Palermo; Francis X. (Washoe, NV), Castel; J. Chris (Washoe, NV)
  • Patent Number: 11/711,285
  • USPTO Link

An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient’s musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.  As used herein, the term “neurological disorder” refers to strokes, traumatic brain injury, cerebral palsy, dystonias, hydrocephalus, etc.

Substituted Piperidines as Modulators of Dopamine Neurotransmission
  • Type(s): Medicine
  • Inventor(s): Sonesson; Clas (Billdal, SE), Swanson; Lars (Ojersjo, SE), Waters; Nicholas (Goteborg, SE)
  • Patent Number: 11/567,886
  • USPTO Link

The present invention relates to compounds having therapeutic effects against disorders in the central nervous system, and in particular substituted hydroxypiperidines of the formula 1: ##STR00001## wherein R1, R2, and R3 are as defined herein. Compounds with modulating effects on dopaminergic systems may also be used to improve cognitive functions and in the treatment of emotional disturbances related to ageing, neurodegenerative (e.g. Dementia and age-related cognitive impairment) and developmental (such as Autism spectrum disorders, ADHD, Cerebral Palsy, Gilles de la Tourette’s syndrome) disorders as well as after brain injury.

Methods of Isolation, Expansion and Differentiation of Fetal Stem Cells from Chorionic Villus, Amniotic Fluid, and Placenta and Therapeutic Uses Thereof
  • Type(s): Medicine
  • Inventor(s): Atala; Anthony (Winston Salem, NC), De Coppi; Paolo (Santa Lucia di Piave, IT)
  • Patent Number: 11/604,917
  • USPTO Link

The present invention is directed to pluripotent fetal stem cells derived from chorionic villus, amniotic fluid, and placenta and the methods for isolating, expanding and differentiating these cells, and their therapeutic uses such as manipulating the fetal stem cells by gene transfection and other means for therapeutic applications. Alternatively, normal allogeneic fetal stem cells may be transplanted. Diseases other than those associated with cells may also be treated, where the disease is related to the lack of a particular secreted product such as hormone, enzyme, growth factor, or the like. CNS disorders encompass numerous afflictions such as neurodegenerative diseases (e.g. Alzheimer’s and Parkinson’s), acute brain injury (e.g. stroke, head injury, cerebral palsy) and a large number of CNS dysfunctions.

Modulation of Neurogenesis by PDE Inhibition
  • Type(s): Medicine
  • Inventor(s): Barlow; Carrolee (Del Mar, CA), Carter; Todd A. (San Diego, CA), Lorrain; Kym I. (San Diego, CA), Pires; Jammieson C. (San Diego, CA), Treuner; Kai (San Diego, CA)
  • Patent Number: 11/551,667
  • USPTO Link

The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a PDE agent, optionally in combination with one or more other neurogenic agents, to stimulate or activate the formation of new nerve cells.  .Non-limiting embodiments of nervous system disorders related to a psychiatric condition include neuropsychiatric disorders and affective disorders. As used herein, an affective disorder refers to a disorder of mood such as, but not limited to, depression, post-traumatic stress disorder (PTSD), hypomania, panic attacks, excessive elation, bipolar depression, bipolar disorder (manic-depression), and seasonal mood (or affective) disorder. Other non-limiting embodiments include schizophrenia and other psychoses, lissencephaly syndrome, anxiety syndromes, anxiety disorders, phobias, stress and related syndromes (e.g., panic disorder, phobias, adjustment disorders, migraines), cognitive function disorders, aggression, drug and alcohol abuse, drug addiction, and drug-induced neurological damage, obsessive compulsive behavior syndromes, borderline personality disorder, non-senile dementia, post-pain depression, post-partum depression, and cerebral palsy.

Method and Apparatus for Utilizing Amplitude-Modulated Pulse-Width Modulation Signals for Neurostimulation and Treatment of Neurological Disorders Using Electrical Stimulation
  • Type(s): Medical Equipment
  • Inventor(s): Hargrove; Jeffrey B. (Bancroft, MI), Stokes; Theodore J. (Lapeer, MI), Esty; Mary L. (Chevy Chase, MD)
  • Patent Number: 11/490,255
  • USPTO Link

A computing device-controlled system is described for the generation of amplitude-modulated pulse-width modulation (AMPWM) signals for use in treating neurological dysfunction via cranial neurostimulation, where the AMPWM signal is specifically designed to minimize the electrical impedance of the tissues of the head. A low-frequency carrier signal is determined for the AMPWM signal by measuring EEG activity at a reference site or sites, generally corresponding with the location of suspected brain dysfunction. Carrier signal frequency is variably related to critical frequency components of the EEG power spectral density, determined from statistical analysis of amplitudes and variability, and dynamically changed as a function of time to prevent entrainment. The AMPWM signal is presented to a subject via a plurality of neurostimulation delivery modes for therapeutic use.

Electromyographic (Emg) Feedback During Ames Treatment of Individuals with Severe Neuromuscular Deficits
  • Type(s): Medical Equipment
  • Inventor(s): Oregon Health & Science University (Portland, OR)
  • Patent Number: 11/487,095
  • USPTO Link

A method of rehabilitating a patient suffering partial or total loss of motor control of an appendicular joint caused by injury or neurological disorder but exhibiting clinically plegic (i.e., paralyzed) muscles and retaining minimal ability to weakly contract the muscles develops overt movement at a joint and ultimately leads to improved functionality. The method entails use of feedback in which the patient views and/or hears a signal related to the intensity of electromyographic (EMG) activity the patient produces in the appropriate muscles while attempting to move the paretic or plegic joint. The method is intended as an alternative form of feedback for highly disabled patients while they receive therapy using an Assisted Movement with Enhanced Sensation (AMES) device providing joint torque feedback. The invention pertains to the use of therapy termed “AMES,” or Assisted Movement with Enhanced Sensation, of a type described in U.S. Pat. No. 6,878,122 in the rehabilitation of patients suffering from stroke, traumatic brain injury, and other neuromuscular disorders such as cerebral palsy and spinal cord injury.

Means for Functional Restoration of a Damaged Nervous system
  • Type(s): Medical Equipment
  • Inventor(s): Bartic; Carmen (Wilsele, BE), Kruth; Jean-Pierre (Heverlee, BE), Nuttin; Bart (Rotselaar, BE)
  • Patent Number: 11/994,374
  • USPTO Link

The present invention relates generally to a method and device of partial or complete functional restoration of the damaged nervous system by bridging a cavity in a tissue of excitable cells e.g. a cavity in the central or peripheral nervous tissue and, more particularly to a system and method for repairing the nerve signal transduction by bridging of the cavity with microelectrode elements more particularly microelectrodes for stimulation and microelectrodes for recording. The bridging device is particularly suitable restoring the interconnectivity between a first excitable cell and a remote second excitable cells of which has been interrupted by a cavity (for instance a stable tissue lesion) and for electrical stimulation of the first remote excitable cells proportional to the activity of the second remote excitable cells. Accordingly, the present invention is particularly suitable for bridging communication of electric stimuli between interrupted or remote excitable cells.

Bilateral Arm Trainer and Method of Use
  • Type(s): Medical Equipment
  • Inventor(s): Whitall; Jill (Annapolis, MD), McCombe-Waller; Sandy (Ellicott City, MD), Grant; David (Towson, MD)
  • Patent Number: 11/353,033
  • USPTO Link

A device and method for bilateral upper extremity training for patients with a paretic upper extremity, the device facilitating cortical remodeling, sustained relearning, and improvement in functional outcomes in paretic and possibly non-paretic upper extremities.A method for cortical remodeling and sensorimotor relearning for a person suffering from neurological damage caused by one from a group consisting of stroke, tumor, injury, and cerebral palsy.

Automated Therapy Device for Biomechanical Rehabilitation Massage and Method for Use
  • Type(s): Medical Equipment
  • Inventor(s): Carkner; Steve (Ottawa, Ontario, CA), Risk; Jamie (Ottawa, Ontario, CA), Blyum; Leonid (Potamos Yermasoya, Limassol, CY)
  • Patent Number: 11/306,263
  • USPTO Link

An automated massage device for biomechanical rehabilitation massage for use on CP patients comprises at least one inflatable bladder with inflation means adapted to provide compressive forces against the body to stimulate smooth muscles in a controlled manner. The device includes a programmable controller that is able to receive instructions on a dynamic prescriptive basis from a professional therapist and then relay these instructions to a care-giver in a home situation. The instructions include the placement of the bladder, the duration of the massage and the sequence of body locations to receive massage therapy. Once the bladder is placed in the required position against the body the device will execute the prescribed massage therapy for that location and then cue the care-giver to move the bladder to the next body location in the prescribed sequence. The prescription is time limited and once expired renders the device inoperable to prevent over application of the massage therapy.

Automated Therapy Device for Biomechanical Rehabilitation Massage and Method for Use
  • Type(s): Medical Equipment
  • Inventor(s): Carkner; Steve (Ottawa, Ontario, CA), Risk; Jamie (Ottawa, Ontario, CA), Blyum; Leonid (Potamos Yermasoya, Limassol, CY)
  • Patent Number: 11/306,263
  • USPTO Link

An automated massage device for biomechanical rehabilitation massage for use on CP patients comprises at least one inflatable bladder with inflation means adapted to provide compressive forces against the body to stimulate smooth muscles in a controlled manner. The device includes a programmable controller that is able to receive instructions on a dynamic prescriptive basis from a professional therapist and then relay these instructions to a care-giver in a home situation. The instructions include the placement of the bladder, the duration of the massage and the sequence of body locations to receive massage therapy. Once the bladder is placed in the required position against the body the device will execute the prescribed massage therapy for that location and then cue the care-giver to move the bladder to the next body location in the prescribed sequence. The prescription is time limited and once expired renders the device inoperable to prevent over application of the massage therapy.

Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions
  • Type(s): Medicine
  • Inventor(s): Johe; Karl K. (Potomac, MD), Hazel; Thomas G. (North Potomac, MD)
  • Patent Number: 11/281,640
  • USPTO Link

A method of treating neurodegenerative conditions is provided. Neural stem cells may be implanted at and/or remote from a region of neuron degeneration. The methods can include isolating neural stem cells from regions where specific types of neurons corresponding to the neurons to be replaced are generated. The methods can include isolating neural stem cells secreting growth factors affecting the growth and/or regeneration of specific types of neuron. In this invention, we disclose a method of treating such disorders, including several neurodegenerative disorders arising from the lack of cells that produce particular neurotransmitters in neural circuitry by transplanting exogenously cultured and expanded neural progenitors which, upon transplantation into a neural tissue, differentiate into neurons capable of integrating and producing neurotransmitters in sufficient quantities and in a sufficient manner to overcome the symptoms associated with the neurodegeneration.

Stimulation System and mMethod for Treating a Neurological Disorder
  • Type(s): Medical Equipment
  • Inventor(s): Thimineur; Mark (Orange, CT), Kravitz; Ed (Milford, CT), Lando; Peter (Plano, TX), Cameron; Tracy (Toronto, CA), Hoare; Rohan (Dallas, TX)
  • Patent Number: 11/189,300
  • USPTO Link

According to one aspect, a stimulation system is provided for electrically stimulating a predetermined site to treat a neurological condition. The system includes an electrical stimulation lead adapted for implantation into a subcutaneous area in communication with a predetermined site, wherein the site is neuronal tissue that is associated with C2/C3 dermatome area, or stimulating cervical nerve roots and/or stimulating cranial nerves and/or stimulating any area associated with the occipital area. The stimulation lead includes one or more stimulation electrodes adapted to be positioned in the predetermined site. The system also includes a stimulation source that generates the stimulation pulses for transmission to the one or more stimulation electrodes of the stimulation lead to deliver the stimulation pulses to the predetermined site to treat a neurological disorder or condition. .In certain embodiments, possibly in combination with one or more of the benefits described above, electrical stimulation of the predetermined site may be provided to effectively treat other neurological disorders for example, but not limited to Developmental Disabilities [e.g., Cerebral Palsy, Mental Retardation, etc

Systems and Methods for Enhancing or Affecting Neural Stimulation Efficiency and/or Efficacy
  • Type(s): Medicine
  • Inventor(s): Gliner; Bradford Evan (Sammamish, WA), Wyler; Allen (Seattle, WA), Fowler; Brad (Woodinville, WA), Sheffield; W. Douglas (Seatac, WA), Kuntz; Richard (Lakebay, WA), Leyde; Kent (Redmond, WA), Sloan; Leif R. (Seattle, WA)
  • Patent Number: 11/182,713
  • USPTO Link

Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient’s nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion. Such neurologic dysfunction and/or conditions may correspond to Parkinson’s Disease, essential tremor, Huntingon’s disease, stroke, traumatic brain injury (TBI), Cerebral Palsy, Multiple Sclerosis, etc.

Reduced Axial Stiffness Implantable Medical Lead
  • Type(s): Medical Equipment
  • Inventor(s): Cross, Jr.; Thomas E. (St. Francis, MN), Olsen; James M. (Plymouth, MN), Bolea; Stephen L. (Watertown, MN)
  • Patent Number: 11/119,416
  • USPTO Link

An implantable lead has a lead body construction designed to accommodate loading forces exerted on the lead body during patient movement. The lead body is sufficiently stretchable to resist forces that could otherwise cause lead failure, axial migration of the electrodes, anchor damage, or tissue damage. The lead body may include a variety of features that reduce the axial stiffness of the lead without significantly impacting the operation and structural integrity of lead components, such as electrodes, conductors and insulators. Neurostimulation systems also include implantable leads for delivery of neurostimulation therapy to patients to treat a variety of symptoms or conditions such as chronic pain, tremor, Parkinson’s disease, multiple sclerosis, spinal cord injury, cerebral palsy, etc.

Methods for Regulation of Stem Cells
  • Type(s): Medicine
  • Inventor(s): Moon; Randall T. (Kenmore, WA), Bhatia; Mickie (London, CA), Trowbridge; Jennifer Jean (Essex, CA)
  • Patent Number: 11/026,399
  • USPTO Link

Methods are provided for increasing stem cells, hematopoietic progenitor/stem cells, mesenchymal progenitor/stem cells, mesodermal progenitor/stem cells, muscle progenitor/stem cells, or neural progenitor/stem cells in vivo in a mammalian subject. Methods are also provided for treating an immune related disease, a mesenchymal/mesoderm degenerative disease, or a neurodegenerative disease in a mammalian subject in need thereof.

Ultrasound Guided High Intensity Focused Ultrasound Treatment of Nerves
  • Type(s): Medical Equipment
  • Inventor(s): Foley; Jessica L. (Seattle, WA), Vaezy; Shahram (Seattle, WA), Little; James W. (Seattle, WA)
  • Patent Number: 11/016,701
  • USPTO Link

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect.  Temporary or permanent blockage by the nerve could also be used to treat spasticity. Spasticity is a complication associated with disorders of the central nervous system (CNS), such as multiple sclerosis, cerebral palsy, stroke,